Please note: Precautionary measures and guidance on safe use concern the use and handling of the specific substance as such, not of the presence of the substance in other articles or mixtures. The CLP Regulation ensures that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union through classification and labelling of chemicals. The POPs Regulation bans or severely restricts the production and use of persistent organic pollutants in the European Union. In one out of the two subjects, the inhalation of a non-irritant concentration of Adipic acid elicited an immediate asthmatic reaction, which was inhibited by the previous administration of Sodium cromoglycate. Self-heating substances and mixtures should reach a temperature of 200°C by self-heating during 24h. Groups of 10 or 19 female rats received food containing 0 or 1 % Adipic acid (0 and approximately 750 mg/kg/day, respectively). Please note that it may take a week or two to have everything fully in place, and please be aware in the meantime that the Registration status may be incorrect and the CLP regulatory context may be incompletely shown. When adipic acid or its sodium salt was administered to non fasted rats, rabbits and one dog 18 – 71 % of the doses were excreted in the urine. <> To unlock this lesson you must be a Study.com Member. Earn Transferable Credit & Get your Degree. A Russian study reported worker inhalation exposure at an Adipic acid manufacturing plant with few details and no histopathology Footnote 13. NTIS/OTSPB245-466. stream If available, additional information on classification and labelling (C&L) is derived from REACH registration dossiers submitted by industry. Beilstein/REAXYS Number 1209788 . ", "Adipic acid was orally administered to humans to investigate compound excretion. This section provides an overview of the calculated volume at which the substance is manufactured or imported to the European Economic Area (EU28 + Iceland, Liechtenstein and Norway). 6(6), Reg. The precautionary measures and guidance on safe use are as submitted to ECHA by registrants under the REACH Regulation. Substances listed in the EINECS, ELINCS, or NLP inventories. This substance is used in the following products: pH regulators and water treatment products, polymers and leather treatment products. Please upgrade your Internet Explorer to a newer version. Although these hazards do not warrant further work, they should nevertheless be noted by chemical safety professionals and users, especially at the workplace.”. Administration of adipic acid to experimental animals has produced patchy livers, irritation of directly exposed organs, haemorrhagic lungs and symptoms of acidosis. The International Agency for Research on Cancer (IARC) and The American Conference of Governmental Industrial Hygienists (ACGIH) have not classified Adipic acid as a carcinogen. In a study combined with 2 year feeding study in rats, histopathological examination of testes, ovaries, and uterus revealed no evidence of an adverse effect on the reproductive organs up to the highest tested doses (3,750 mg/kg/day in males, 750 mg/kg/day in females) Footnote 11. The classification criteria for Pyrophoric Gases do not apply to this substance. Another case report of occupation asthma was reported in a 43 year old female who was handling a solder wire containing an Adipic-acid-flux Footnote 5. 2(b)(i) - Hazardous Agents, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, FCM and Articles Regulation, Annex I - Authorised Substances, Workplace Signs - minimum requirements & signs on containers and pipes. Molecular Weight 146.14 . Where does nylon come from though and how do chemists use it to provide things and materials we depend on daily for our lives? No difference in body weights was found in female and male rats receiving 0, 0.1, and 1 % Adipic acid; however, the weight gains of the male rats receiving 3 and 5 % Adipic acid were significantly less than the control groups. For a detailed overview on identified uses and environmental releases, please consult the registered substance factsheet. In a key study performed according to OECD TG 405 and in compliance with GLP, application of 100 mg of Adipic acid (>99.8%) into the conjunctival sac of the right eye of 3 rabbits caused severe irritation (based on study summary Footnote 3). This site is not fully supported in Internet Explorer 7 (and earlier versions). The CLP Regulation uses the UN Global Harmonised System (GHS) and European Union Specific Hazard Statements (EUH). John Wiley & Sons, Inc., New York. Hazards identified by OECD/ICCA high production volume chemicals program in 2004: "After oral administration by gavage of radioactive adipic acid to fasted rats up to 70 % of the dose was exhaled as CO2. The type of uses and classifications may vary between different submissions to ECHA and for a full understanding it is recommended to consult the source data. Quiz & Worksheet - Adipic Acid Uses & Dangers, Over 83,000 lessons in all major subjects, {{courseNav.course.mDynamicIntFields.lessonCount}}, What is Acrylic Acid? just create an account. According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance causes serious eye irritation. For more information, see the Technical Guidance on the Requirements of the Hazardous Products Act (HPA) and the Hazardous Products Regulations (HPR) – WHMIS 2015 Supplier Requirements. All of the other carbon atoms in adipic acid contain two hydrogens each, and these carbons are called saturated carbons, because they contain the maximum number of hydrogens that they can possibly accommodate. Linear Formula HOOC(CH 2) 4 COOH . 1960). Mutation Research 260:4:321-330. Adipic acid was metabolized by beta-oxidation in a similar fashion as fatty acids and acetate was a metabolite of adipic acid. No animal data are available. The ‘Hazard classification and labelling’ section shows the hazards of a substance based on the standardised system of statements and pictograms established under the CLP (Classification Labelling and Packaging) Regulation.